The aim of this research is to design a role engagement model of human resources in an Islamic organization with a Quranic approach. This qualitative research is a type of content analysis which was, in the first stage, carried out through the study of existing literature. and then, by the reflection in Holy Quran method with a problem-oriented strategy; the elements were derived from using a deductive method. The samples of 69 verses in Quran were selected using an aim-oriented approach, until leading up to a category saturation. The samples were analyzed by way of the concept-finding of reflection in Holy Quran method. According to the findings of this research, the Quranic model includes pervasive themes of the concept, antecedents and consequences of role engagement. The faith and good deed were found as two basic themes of the concept. The basic themes of antecedents are organized into organizational antecedents such as leadership characteristics, and personal antecedents such as personal characteristics. Also, the basic themes of consequences are organized into organizational consequences such as organizational success and survival, and personal consequences such as work-life balance. In this research, Itghan and Efadah were used to test the validity and reliability of the results, accordingly. The findings of this research can lead to the development of theoretical knowledge of human resource management and also the application of religious and spiritual value concepts in modern organizations especially cultural, educational and upbringing institutions.